A landmark sanctuary provides shivers of recognition to fans of "Vertigo.". In Short The same week the Founding Fathers were declaring U.S. independence, aboriginal labor began on this, the oldest intact building in San Francisco. Thirty-six thousand sun-dried bricks later, Mission San Francisco de Asis is where the story of San Francisco begins. Included in this lavish, historical building is a small museum containing religious artifacts as well as historical tales from the Mission District. The museum has remained culturally significant, acting as the center of a vibrant, diverse parish.